Pathophysiological basis of translational stroke research
Translational Stroke Research focuses on translational research and is relevant to both basic scientists and physicians, including but not restricted to neuroscientists, vascular biologists, neurologists, neuroimagers, and neurosurgeons. The Journal provides an interactive forum for the dissemination of original research articles, review articles, research reports, letters, comments, and research protocols, in stroke and strokeWith this tracer the pathophysiological changes early after ischemic stroke could be accurately specified: 55 of the volume of the final infarct had FMZ uptake indicative of infarction in the first hours after stroke; 21 of the final infarct had flow below 14 ml100 gmin, but FMZ uptake above the critical value, thereby indicating penumbra pathophysiological basis of translational stroke research
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for stroke in AF patients (190) and is found in 20 of all patients with AF (396, 416). The high prevalence of diabetes mellitus in AF populations suggests that diabetes may either cosegregate with AF due to similar conditions that cause both AF and diabetes, or may imply that diabetes mellitus plays a causative role in the occurrence of AF.
The poor translational power of preclinical stroke studies has led to the establishment of the Stroke Therapy Academic Industry Roundtable who issues regularly updated recommendations to improve the quality of preclinical stroke research (Fisher et al, 2009). Important aspects of these recommendations are the precise definition of the time window of treatment, the use of both permanent and transient
To describe the pathophysiological basis linking cardiovascular disease (CVD) and depression; to discuss the causal relationship between them, and to review the effects of antidepressant treatment on cardiovascular disease. Depression and cardiovascular disease are both highly prevalent. Several
The pathophysiology of obesity involves many possible pathophysiological mechanisms involved in its development and maintenance. This field of research had been almost unapproached until the leptin gene was discovered in 1994 by J. M. Friedman's laboratory. These investigators postulated that leptin was a satiety factor.
The macrosphere modelan embolic stroke model for studying the pathophysiology of focal cerebral ischemia in a translational approach Maureen Walberer1, 2, 3, Maria Adele Rueger1, 2 1Department of Neurology, University Hospital of Cologne, Cologne, Germany; 2MaxPlanckInstitute for Metabolism Research, Cologne,
Clinical Neuroscience group is a multidisciplinary team of professionals that aims to elucidate the pathophysiological basis of stroke and investigate better preclinical models by assemble collaborative and novel therapeutic tools for stroke patients. Our studies have direct bearing on AIS patients, offer insights into potential therapies (remote ischemic tolerance) and
This project is supported in part by the NIH Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) Network, and NINDS grant 3P50NS to Washington University in St. Louis School of Medicine and UT Southwestern Medical Center.
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